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Anadrol Side Effects: Anadrol is an orally active C-17 alpha alkylated anabolic steroid, and as such, it exhibits hepatotoxicity and negative effects where the liver is concerned. It has been shown to cause the liver to produce an increase in lipid peroxidation, especially in the liver of the male. The hepatotoxicity of anadrol was previously suggested to be related to its action as an anabolic drug and it has been shown that there is an increased risk of hepatic injury related to inositol phosphates and related lipid peroxidation. The liver's action does not appear to be related to drug metabolism such as conversion of anabolic steroids into androstenedione, or to the action of other anabolic steroids. Anadrol is also reported to produce increases in serum androgen levels; this has also been shown to occur with several other anabolic steroids. An increase in testosterone also has been reported with dosed-up steroids.Clinical Pharmacology: Anadrol has been reported to be a potent diuretic and has the ability to excrete the urinary system in the human during the active drug phase. It appears that high doses of anadrol, especially in the female population, have the side effect of hypothermia. It can also cause hypothermia when administered to a pregnant woman. Anadrol is not a drug for pregnant women and it has not been shown to harm a person breastfeeding, although it may damage the placenta. The most widespread effect of anadrol is an increase in circulating triglyceride. Increased triglyceride levels may also be related to an increase in free fatty acids and hence lipogenesis, causing increased oxidation of triglycerides in the liver and liver fatty acid oxidation during the lactation period. Increased concentrations of free fatty acids in breast milk, and in the neonate, are linked to hepatic damage. These changes also may be linked to the onset of puberty. An increase in triglycerides does not appear to affect a person at rest, but it can be associated with fatigue.Human Pharmacology: It has been shown in rats and rodents that doses of 0.5 to 2 mg/kg per day have a strong negative effect on the metabolism and liver function of fatty acids. The liver of the animal was observed to be much more sensitive to this effect than the liver of an adult human. This appears to be a consequence of the reduced hepatic metabolism of non-esterified fatty acids. It is noteworthy that the effects in the rat are reversible, whereas the liver of adult subjects has a normal rate of oxidation. This suggests the possibility that this effect of anadrol upon a young mammal does not need to be consideredRelated Article: